Incurin
Estriol
Marketing authorisation holder and manufacturer responsible for batch release:
Intervet International B.V. Wim de Körverstraat 35 5831 AN Boxmeer
The Netherlands
INCURIN 1 mg tablet Estriol
Active substance: estriol 1 mg/tablet Round single-scored tablets.
Incurin is indicated for the treatment of hormone-dependent urinary incontinence due to sphincter mechanism incompetence in female dogs.
Do not use in intact bitches, as the efficacy has only been established in ovariohysterectomised bitches.
Animals showing a polyuria-polydipsia should not be treated with Incurin.
The use of Incurin is contraindicated during pregnancy, lactation and in animals younger than 1 year.
Mild, oestrogenic effects such as swollen vulva, swollen teats and/or attractiveness for males have been observed at the high dose of 2 mg. These effects are reversible after lowering the dose. Further, in some dogs, symptoms of nausea were observed. Because of its short-acting oestrogenic properties, Incurin does not induce bone marrow suppression in the dog.
In rare cases vaginal bleeding occurred. In rare cases development of alopecia has also been observed.
If you notice any serious effects or other effects not mentioned in this leaflet, please inform your veterinary surgeon.
Dog.
Incurin is intended for once daily oral administration.
Since there exists no relation between the final effective dose and the body weight, a fixed dose per kg body weight is not feasible. The dose has to be fixed for each dog on an individual basis. The
following dosing schedule is advised: start treatment with 1 tablet every day. If treatment is successful
lower the dose to half a tablet a day. If treatment is not successful increase the dose to 2 tablets a day. Some dogs do not need daily treatment; treatment every other day may be tried once the effective daily dose has been established.
Not applicable.
Not applicable.
Keep out of the reach and sight of children. Do not store above 30°C.
Do not use after the expiry date which is stated on the label after Exp.
High doses of oestrogen may have a tumour-promoting effect in target organs with oestrogen receptors (mammary glands).
In case of overdose typical oestrogen effects may occur. These effects are reversible after lowering the dose.
Ask your veterinary surgeon how to dispose of medicines no longer required. These measures should help to protect the environment.
Each push-through strip contains 30 tablets. Each strip is packed in a carton box.
Oestriol is a short-acting natural oestrogen. In the incontinent female dog it has a beneficial effect on the urinary incontinence. Upon oral administration a steady state is reached after the second treatment day and no accumulation occurs after multiple dosing. Because of its short acting action, oestriol does not induce bone marrow suppression in the dog.
For any information about this veterinary medicinal product, please contact the local representative of the marketing authorisation holder.