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AstraZeneca

Signifor
pasireotide

Package leaflet: Information for the user


Signifor 0.3 mg solution for injection Signifor 0.6 mg solution for injection Signifor 0.9 mg solution for injection pasireotide


Read all of this leaflet carefully before you start using this medicine because it contains important information for you.


Warnings and precautions

Talk to your doctor before using Signifor if you currently have or have ever had:

- medicines to control the balance of electrolytes (potassium, magnesium) in your body.


It is particularly important that you mention any of the following medicines:


  1. Contents of the pack and other information What Signifor contains


To reduce local discomfort, it is recommended that the solution is at room temperature before administration.


Ampoules should be opened just prior to administration, and any unused portion discarded.


Check the expiry date and the dose

Check the expiry date which is stated on the ampoule label (after “EXP”) and check that the ampoule contains the dose that your doctor has prescribed.


DO NOT USE if the medicine has expired or if the dose is incorrect. In both these cases, return the entire pack to the pharmacy.

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How to inject Signifor


Step 1:

Signifor solution for injection is filled in a break-off

ampoule. The coloured dot on the top part marks the position of the breaking point on the neck of the ampoule. Tap the ampoule with your finger in order to make sure there is no liquid in the top part when you open the ampoule.


Step 2:

Recommended procedure: hold the ampoule in an

upright position with the coloured dot facing away from you. Hold the base of the ampoule in one hand.

Keeping your thumbs together above and below the

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neck, break off the top of the ampoule at the breaking point. Once the ampoule is open, put it upright on a clean, flat surface.


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Step 3:

Take the sterile syringe and attach the needle to it. If

you have been told to use two needles, you should use the long thick blunt one for this step.


Before you proceed to step 4, clean the injection site with an alcohol wipe.

Remove the cover from the needle. Put the needle into the ampoule and pull the plunger to draw up the entire contents of the ampoule into the syringe.

If you have been told to use two needles, you should now replace the long needle with the short one.


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Step 5:

Hold the syringe in one hand between two fingers with your thumb at the bottom of the plunger. Tap the syringe with your fingers to get rid of air bubbles.

Make sure there is no air bubble in the syringe by pressing the plunger until the first drop appears on the

tip of the needle.

Do not let the needle touch anything. You are now ready to inject.


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Step 6:

Gently pinch the skin at the injection site and, holding the needle at an angle of approximately 45 degrees (as shown in the picture) insert it into the injection site.

Pull slightly on the plunger to check that a blood vessel has not been punctured. If you see blood in the

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syringe, first remove the needle from the skin, then replace the short needle with a new one and insert it into a different injection site.


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Step 7:

Always keeping your skin pinched, slowly press the

plunger down as far as it will go untilallthesolution isinjected. Keep the plunger pressed down and hold

the syringe in place for 5 seconds.

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Slowly release the skin fold and gently pull the needle out. Put the cover back on the needle.


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Step 9:

Dispose of the used syringe and needle immediately in

a sharps container or other rigid closed disposal container. Any unused product or waste material should be disposed of in accordance with local requirements.