Advasure
Adjuvanted vaccine against classical swine fever
15/20
authorised
no
Medicinal
Medicinal Product no longer authorised
Pfizer Ltd. Sandwich
Kent, CT13 9NJ
United Kingdom
Bayer AG
Business Group Animal Health Osterather Strasse 1a
D-50739 Köln
Germany
Advasure
Per dose of 2 ml:
E2 glycoprotein of Classical Swine Fever (CSF) virus minimum 32 µg
Adjuvant composition - Double oil emulsion:
Mineral oil 0.64 ml
Emulsifiers 0.064 ml
Phosphate buffered saline 0.63 ml
Thiomersal maximum 1:10,000
Active immunisation of pigs, over the age of 2 weeks, against Classical Swine Fever (CSF), to prevent mortality, reduce clinical signs of the disease and the excretion of field virus.
The onset of protection is 2 weeks. The duration of protection is 6 months.
None
Medicinal Product no longer authorised
If you notice any serious effects or other effects not mentioned in this leaflet, please inform your veterinary surgeon.
Pigs
The dosage for pigs, over 2 weeks, is 2 ml of the vaccine Intramuscular injection
The vaccine is to be administered aseptically by intramuscular injection closely behind the ear of the pig.
The pigs should be vaccinated in time before the expected exposure to the field virus, preferably prior to housing (crowding) or transfer to new groups. It is strongly recommended to vaccinate all pigs in the herd.
The dosage for pigs, over the age of 2 weeks, is 2 ml of the vaccine.
In emergency situations the basic immunisation consists of one intramuscular injection with one dose (2 ml) for all pigs over the age of 2 weeks, irrespective of the level of maternal antibodies.
Depending on the infection pressure and the disease situation sows and piglets over the age of 2 weeks (irrespective of the level of maternal antibodies) may be vaccinated twice with one dose (2 ml), 4–6 weeks apart. For fattening pigs over the age of 10 weeks, however, one intramuscular injection with one dose is administered.
Re-vaccination:
one dose (2 ml) at 6 months intervals.
Can be used during pregnancy. The vaccine has been shown to prevent transplacental transmission of low virulence strains after two vaccinations of the sow. However it may not prevent transplacental transmission of highly virulent strains from the sow to the foetuses.
Zero days
Store out of reach and sight of children.
Store at 2°C – 8°C Do not freeze. Protect from light. Do not use after the expiry date stated on the label.
Medicinal Product no longer authorised
The use of immunosuppressive veterinary medicinal products (e.g. corticosteroids) or modified live Porcine Reproductive and Respiratory Syndrome (PRRS) vaccines within 7 days before and 7 days after application of Advasure may interfere with the induction of immunity and should therefore be avoided.
Do not mix with any other vaccine/immunological product. To the user:
This product contains mineral oil. Accidental injection/self injection may result in severe pain and swelling, particularly if injected into a joint or finger, and in rare cases could result in the loss of the affected finger if prompt medical attention is not given. If you are accidentally injected with this product, seek prompt medical advice even if only a very small amount is injected and take the package insert with you. If pain persists for more than 12 hours after medical examination, seek medical advice again.
To the physician:
This product contains mineral oil. Even if small amounts have been injected, accidental injection with this product can cause intense swelling, which may, for example, result in ischaemic necrosis and even the loss of a digit. Expert, PROMPT, surgical attention is required and may necessitate early incision and irrigation of the injected area, especially where there is involvement of finger pulp or tendon.
The import, sale, supply and/or use of this veterinary medicinal product is only allowed under the particular conditions established by European Community legislation on the control of CSF (Council Directive 80/217/EEC, as amended). Any person intending to import, sell, supply and/or use the veterinary medicinal product must be authorised by the competent authority of the Member State.
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
13-02-2006
The Classical Swine Fever (CSF, Hog Cholera) virus, a member of the Pestivirus genus, carries a number of structural and non-structural glycoproteins, e.g. E2, E1, Erns, gp54, gp80. The E2 glycoprotein is considered to be the main immunogen of the CSF virus against which the neutralising antibodies are directed. The gene coding for the E2 glycoprotein (E2 gene) is a rather conserved region. The E2 glycoprotein is considered to be immunologically cross-reactive with all field strains.
Medicinal Product no longer authorised
Immunological properties:
The vaccine, as formulated with the mineral oil and the emulsifiers, induces protection in pigs against clinical signs caused by the Classical Swine Fever (CSF) virus. As a consequence of the subunit nature of the vaccine, vaccination does not induce production of antibodies against CSF virus antigens, other than E2.
For any information about this veterinary medicinal product, please contact the local representative of the Marketing Authorisation Holder.
Tel./Tél.: +32 (0)2 554 62 11
Tél.: + 32 (0)2 554 62 11
Tlf: +45 49 12 76 65
Tel: +31 (0)10 4064 600
Tel: +49 (0)721 6101 438
Tel: +43 (0)1 52 11 57 20
Tel: +30 210 7517981
Telefone: +351 21 2278200
Teléfono: +34 91 4909900
Telephone: +358 (0)9 4300 40
Téléphone: +33 (0)1 58 07 46 00
Tel: +46 (0)8 623 64 40
Telephone: +353 (0)1 408 9700
Telephone: +44 (0)1304 616161
Telefono: +39 06 3318 2933
Tel: +420 283 004 111
Tel: +361 488 3695
Tel: +356 21 465 797
Tel: +370 5 269 17 96
Tel: +48 22 550 42 32
Medicinal Product no longer authorised
Tel: +386 (0) 1 52 11 670
Tel: +420 283 004 111
Tel: +30 210 7517981
Tel: +370 5 269 17 96
Tel: +370 5 269 17 96